BDBM50119922 2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-((2R,3R)-2,3-dimethyl-2,3-dihydro-indol-1-yl)-ethanone::CHEMBL326670
SMILES: C[C@@H]1[C@H](C)c2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1
InChI Key: InChIKey=PASKDVYJTCOFHQ-ZWKOTPCHSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50119922 (2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-((2R,3R)-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | Bioorg Med Chem Lett 12: 3105-9 (2002) BindingDB Entry DOI: 10.7270/Q2JM2908 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50119922 (2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-((2R,3R)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand | Bioorg Med Chem Lett 12: 3105-9 (2002) BindingDB Entry DOI: 10.7270/Q2JM2908 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50119922 (2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-((2R,3R)-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]prazosin as radi... | Bioorg Med Chem Lett 12: 3105-9 (2002) BindingDB Entry DOI: 10.7270/Q2JM2908 | |||||||||||
More data for this Ligand-Target Pair |