BDBM50120096 4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]quinoxaline-8-carbonitrile::4-(2-chloro-6-methylphenylamino)imidazo[1,5-a]quinoxaline-8-carbonitrile::CHEMBL423321

SMILES: Cc1cccc(Cl)c1Nc1nc2ccc(cc2n2cncc12)C#N

InChI Key: InChIKey=NLWQEFDCZXNPDB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50120096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50120096 (4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]qu...) Show SMILES Cc1cccc(Cl)c1Nc1nc2ccc(cc2n2cncc12)C#N Show InChI InChI=1S/C18H12ClN5/c1-11-3-2-4-13(19)17(11)23-18-16-9-21-10-24(16)15-7-12(8-20)5-6-14(15)22-18/h2-7,9-10H,1H3,(H,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Lck				J Med Chem 51: 1179-88 (2008) Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50120096 (4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]qu...) Show SMILES Cc1cccc(Cl)c1Nc1nc2ccc(cc2n2cncc12)C#N Show InChI InChI=1S/C18H12ClN5/c1-11-3-2-4-13(19)17(11)23-18-16-9-21-10-24(16)15-7-12(8-20)5-6-14(15)22-18/h2-7,9-10H,1H3,(H,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description 50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.				Bioorg Med Chem Lett 12: 3153-6 (2002) BindingDB Entry DOI: 10.7270/Q2NC60JR
					More data for this Ligand-Target Pair