BDBM50121028 CHEMBL113761::[(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-2-phenyl-propyl]-carbamic acid benzyl ester
SMILES: O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@H]2OCCN2C1=O)OCc1ccccc1
InChI Key: InChIKey=VYRSXJDNPISAMG-WAOWUJCRSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin K (Homo sapiens (Human)) | BDBM50121028 (CHEMBL113761 | [(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin K cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin L (Rattus norvegicus) | BDBM50121028 (CHEMBL113761 | [(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyc...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM50121028 (CHEMBL113761 | [(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin B cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin S (Homo sapiens (Human)) | BDBM50121028 (CHEMBL113761 | [(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair |