BDBM50121164 3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-benzonitrile::3-(3,3-dimethyl-2-oxoindolin-5-yl)benzonitrile::CHEMBL117187

SMILES: CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)C#N

InChI Key: InChIKey=WZZPSUKZMZKXTQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50121164 (3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C17H14N2O/c1-17(2)14-9-13(6-7-15(14)19-16(17)20)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase				J Med Chem 51: 1861-73 (2008) Article DOI: 10.1021/jm701080t BindingDB Entry DOI: 10.7270/Q2G44R56
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50121164 (3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C17H14N2O/c1-17(2)14-9-13(6-7-15(14)19-16(17)20)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...				Bioorg Med Chem Lett 12: 3487-90 (2002) BindingDB Entry DOI: 10.7270/Q2R210RC
					More data for this Ligand-Target Pair