BDBM50121180 5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2'(1'H)-one::CHEMBL324115

SMILES: Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1

InChI Key: InChIKey=XVGXCHRWZFIARX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50121180   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50121180 (5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...) Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1 Show InChI InChI=1S/C19H18ClNO/c20-15-6-4-5-13(11-15)14-7-8-17-16(12-14)19(18(22)21-17)9-2-1-3-10-19/h4-8,11-12H,1-3,9-10H2,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...				Bioorg Med Chem Lett 12: 3487-90 (2002) BindingDB Entry DOI: 10.7270/Q2R210RC
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50121180 (5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...) Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1 Show InChI InChI=1S/C19H18ClNO/c20-15-6-4-5-13(11-15)14-7-8-17-16(12-14)19(18(22)21-17)9-2-1-3-10-19/h4-8,11-12H,1-3,9-10H2,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	477	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol				Bioorg Med Chem Lett 12: 3487-90 (2002) BindingDB Entry DOI: 10.7270/Q2R210RC
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50121180 (5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...) Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1 Show InChI InChI=1S/C19H18ClNO/c20-15-6-4-5-13(11-15)14-7-8-17-16(12-14)19(18(22)21-17)9-2-1-3-10-19/h4-8,11-12H,1-3,9-10H2,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against progesterone receptor induced alkaline phosphatase activity in human T47D breast carcinoma cells				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
					More data for this Ligand-Target Pair