BDBM50121389 CHEMBL3622139

SMILES: CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)NC1CC1

InChI Key: InChIKey=FPVYKGCVYPJWOX-JTQLQIEISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50121389 (CHEMBL3622139) Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)NC1CC1 |r| Show InChI InChI=1S/C17H22N6O3/c1-18-15-13-14(22(2)8-19-13)11-5-12(17(26)20-9-3-4-9)23(16(11)21-15)6-10(25)7-24/h5,8-10,24-25H,3-4,6-7H2,1-2H3,(H,18,21)(H,20,26)/t10-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay				ACS Med Chem Lett 6: 845-9 (2015) BindingDB Entry DOI: 10.7270/Q2Q2421M
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50121389 (CHEMBL3622139) Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)NC1CC1 |r| Show InChI InChI=1S/C17H22N6O3/c1-18-15-13-14(22(2)8-19-13)11-5-12(17(26)20-9-3-4-9)23(16(11)21-15)6-10(25)7-24/h5,8-10,24-25H,3-4,6-7H2,1-2H3,(H,18,21)(H,20,26)/t10-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay				ACS Med Chem Lett 6: 845-9 (2015) BindingDB Entry DOI: 10.7270/Q2Q2421M
					More data for this Ligand-Target Pair