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SMILES: Cc1nc(cs1)C#Cc1cncc(C)c1

InChI Key: InChIKey=FNYSJYOTGKRVBK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50123009   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50123009 (3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine...) Show SMILES Cc1nc(cs1)C#Cc1cncc(C)c1 Show InChI InChI=1S/C12H10N2S/c1-9-5-11(7-13-6-9)3-4-12-8-15-10(2)14-12/h5-8H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	3	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Wo...				US Patent US8609852 (2013) BindingDB Entry DOI: 10.7270/Q27M06K3
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50123009 (3-Methyl-5-(2-methyl-thiazol-4-ylethynyl)-pyridine...) Show SMILES Cc1nc(cs1)C#Cc1cncc(C)c1 Show InChI InChI=1S/C12H10N2S/c1-9-5-11(7-13-6-9)3-4-12-8-15-10(2)14-12/h5-8H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro functional potency using an automated assay employing LtK-cells stably expressing human recombinant mGlu5 receptor by measuring changes in c...				Bioorg Med Chem Lett 13: 351-4 (2003) BindingDB Entry DOI: 10.7270/Q2H995RQ
					More data for this Ligand-Target Pair