BDBM50124331 CHEMBL262056::N-{3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-phenyl}-2-piperidin-1-yl-acetamide

SMILES: Nc1nc(cc(-c2cccc(NC(=O)CN3CCCCC3)c2)c1C#N)-c1ccccc1O

InChI Key: InChIKey=QISTVOQRBVFVDC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124331   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50124331 (CHEMBL262056 | N-{3-[2-Amino-3-cyano-6-(2-hydroxy-...) Show SMILES Nc1nc(cc(-c2cccc(NC(=O)CN3CCCCC3)c2)c1C#N)-c1ccccc1O Show InChI InChI=1S/C25H25N5O2/c26-15-21-20(14-22(29-25(21)27)19-9-2-3-10-23(19)31)17-7-6-8-18(13-17)28-24(32)16-30-11-4-1-5-12-30/h2-3,6-10,13-14,31H,1,4-5,11-12,16H2,(H2,27,29)(H,28,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 619-0216 Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against recombinant human IkB kinase beta (IKK-beta)				Bioorg Med Chem Lett 13: 913-8 (2003) BindingDB Entry DOI: 10.7270/Q2TM7BP1
					More data for this Ligand-Target Pair