BDBM50124771 CHEMBL3622940

SMILES: Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1

InChI Key: InChIKey=VJYCBOJERLUZIA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124771 (CHEMBL3622940) Show SMILES Cc1cn(cc1CN1CC(O)C1)-c1ccnc(Nc2cc(C)c(OCC(=O)N3CCCC3)c(C)c2)n1 Show InChI InChI=1S/C27H34N6O3/c1-18-10-22(11-19(2)26(18)36-17-25(35)32-8-4-5-9-32)29-27-28-7-6-24(30-27)33-12-20(3)21(14-33)13-31-15-23(34)16-31/h6-7,10-12,14,23,34H,4-5,8-9,13,15-17H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair