BDBM50125020 CHEMBL349606::N-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[(R)-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethyl)-4-phenylmethanesulfonyl-piperazin-1-yl]-acetamide
SMILES: NC(=N)NCCC[C@H](NC(=O)CN1CCN([C@H](CC(=O)N2CCCCC2)C1=O)S(=O)(=O)Cc1ccccc1)C(=O)c1nccs1
InChI Key: InChIKey=BMORWMVRWCHRDH-XZOQPEGZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50125020 (CHEMBL349606 | N-[(S)-4-Guanidino-1-(thiazole-2-ca...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity against serine protease thrombin | Bioorg Med Chem Lett 13: 729-32 (2003) BindingDB Entry DOI: 10.7270/Q2T72GTS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50125020 (CHEMBL349606 | N-[(S)-4-Guanidino-1-(thiazole-2-ca...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity against factor Xa | Bioorg Med Chem Lett 13: 729-32 (2003) BindingDB Entry DOI: 10.7270/Q2T72GTS | |||||||||||
More data for this Ligand-Target Pair |