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SMILES: [O-][n+]1ccc(CC(c2ccc(NS(=O)(=O)c3ccccc3)nc2)c2ccc(OC(F)F)c(OC(F)F)c2)cc1

InChI Key: InChIKey=MHHVHHXUMOLHOJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50125058   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))		BDBM50125058
PNG
(CHEMBL162870 | N-{5-[1-(3,4-Bis-difluoromethoxy-ph...)
Show SMILES [O-][n+]1ccc(CC(c2ccc(NS(=O)(=O)c3ccccc3)nc2)c2ccc(OC(F)F)c(OC(F)F)c2)cc1
Show InChI InChI=1S/C26H21F4N3O5S/c27-25(28)37-22-8-6-18(15-23(22)38-26(29)30)21(14-17-10-12-33(34)13-11-17)19-7-9-24(31-16-19)32-39(35,36)20-4-2-1-3-5-20/h1-13,15-16,21,25-26H,14H2,(H,31,32)
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KEGG

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PC cid
PC sid
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PubMed
n/an/a 16n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against human PDE4A expressed isoform using construct representing the common region of spliced variants as GST-fusion protein in...

Bioorg Med Chem Lett 13: 741-4 (2003)


BindingDB Entry DOI: 10.7270/Q2PG1R3G
More data for this
Ligand-Target Pair