BDBM50125409 7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid::CHEMBL280223
SMILES: OC(\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O)C1(CC1)c1ccccc1
InChI Key: InChIKey=DVDIXSPSNQPVNX-QHYGYJHXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Binding affinity was determined against prostanoid EP4 receptor | Bioorg Med Chem Lett 14: 1655-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.063 BindingDB Entry DOI: 10.7270/Q2MK6CBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid DP receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid IP receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Binding affinity was determined against prostanoid EP3 receptor | Bioorg Med Chem Lett 14: 1655-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.063 BindingDB Entry DOI: 10.7270/Q2MK6CBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Binding affinity was determined against prostanoid EP1 receptor | Bioorg Med Chem Lett 14: 1655-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.063 BindingDB Entry DOI: 10.7270/Q2MK6CBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.64E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Binding affinity was determined against prostanoid EP2 receptor | Bioorg Med Chem Lett 14: 1655-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.063 BindingDB Entry DOI: 10.7270/Q2MK6CBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50125409 (7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells | Bioorg Med Chem Lett 14: 1655-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.063 BindingDB Entry DOI: 10.7270/Q2MK6CBC | |||||||||||
More data for this Ligand-Target Pair |