BDBM50125662 (S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-methyl-pentanoic acid ((1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-oxo-4-phenyl-butyl)-amide::(S)-N-((2S,3R)-1-cyclohexyl-3-hydroxy-4-oxo-5-phenylpentan-2-yl)-2-(2-(3,5-difluorophenyl)acetamido)-4-methylpentanamide::CHEMBL19616

SMILES: CC(C)C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1

InChI Key: InChIKey=BJMNUVVFPQVFTR-FEVNIDIWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50125662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50125662 ((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...) Show SMILES CC(C)C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C31H40F2N2O4/c1-20(2)13-27(34-29(37)18-23-14-24(32)19-25(33)15-23)31(39)35-26(16-21-9-5-3-6-10-21)30(38)28(36)17-22-11-7-4-8-12-22/h4,7-8,11-12,14-15,19-21,26-27,30,38H,3,5-6,9-10,13,16-18H2,1-2H3,(H,34,37)(H,35,39)/t26-,27-,30+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.				Bioorg Med Chem Lett 13: 1203-6 (2003) BindingDB Entry DOI: 10.7270/Q279442Z
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