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SMILES: CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)CCC(C)C

InChI Key: InChIKey=TZMDKHIHZYZUIC-JAXLGGSGSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50125669   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50125669
PNG
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(S)-4-methyl-2-(...)
Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)CCC(C)C
Show InChI InChI=1S/C24H44N2O5/c1-6-31-24(30)22(28)19(15-18-10-8-7-9-11-18)26-23(29)20(14-17(4)5)25-21(27)13-12-16(2)3/h16-20,22,28H,6-15H2,1-5H3,(H,25,27)(H,26,29)/t19-,20-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.

Bioorg Med Chem Lett 13: 1203-6 (2003)


BindingDB Entry DOI: 10.7270/Q279442Z
More data for this
Ligand-Target Pair