BDBM50126030 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24271

SMILES: Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12

InChI Key: InChIKey=GTURWVWPNOUBNH-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126030 (4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...) Show SMILES Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H21N3O/c1-33-21-32-20-29(33)30(34,17-16-22-8-3-2-4-9-22)25-15-14-24(19-31)28(18-25)27-13-7-11-23-10-5-6-12-26(23)27/h2-15,18,20-21,34H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50126030 (4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...) Show SMILES Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H21N3O/c1-33-21-32-20-29(33)30(34,17-16-22-8-3-2-4-9-22)25-15-14-24(19-31)28(18-25)27-13-7-11-23-10-5-6-12-26(23)27/h2-15,18,20-21,34H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of farnesylation in NIH-3T3H-ras cell line				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50126030 (4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-pheny...) Show SMILES Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H21N3O/c1-33-21-32-20-29(33)30(34,17-16-22-8-3-2-4-9-22)25-15-14-24(19-31)28(18-25)27-13-7-11-23-10-5-6-12-26(23)27/h2-15,18,20-21,34H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-Ras				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
					More data for this Ligand-Target Pair