BDBM50126343 5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2''-methyl-biphenyl-2-carbonitrile::5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL28937

SMILES: Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C

InChI Key: InChIKey=WNWCSJWUFYSYRF-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50126343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50126343 (5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2...) Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C Show InChI InChI=1S/C26H23N3O/c1-19-8-6-7-11-23(19)24-14-21(12-13-22(24)15-27)26(25-16-28-18-29(25)2)30-17-20-9-4-3-5-10-20/h3-14,16,18,26H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine farnesyl transferase				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50126343 (5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2...) Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C Show InChI InChI=1S/C26H23N3O/c1-19-8-6-7-11-23(19)24-14-21(12-13-22(24)15-27)26(25-16-28-18-29(25)2)30-17-20-9-4-3-5-10-20/h3-14,16,18,26H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against farnesyltransferase (FTase)				Bioorg Med Chem Lett 13: 1367-71 (2003) BindingDB Entry DOI: 10.7270/Q20K27ZP
					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50126343 (5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2...) Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C Show InChI InChI=1S/C26H23N3O/c1-19-8-6-7-11-23(19)24-14-21(12-13-22(24)15-27)26(25-16-28-18-29(25)2)30-17-20-9-4-3-5-10-20/h3-14,16,18,26H,17H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in NIH 3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50126343 (5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2...) Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C Show InChI InChI=1S/C26H23N3O/c1-19-8-6-7-11-23(19)24-14-21(12-13-22(24)15-27)26(25-16-28-18-29(25)2)30-17-20-9-4-3-5-10-20/h3-14,16,18,26H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine geranyl geranyl transferase				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair