BDBM50126742 2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL29488

SMILES: CN1CCN(CC1)C(=O)Cc1c(C)[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc12

InChI Key: InChIKey=SWMSQLFGVFMRIQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126742   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50126742 (2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-[2-(4-...) Show SMILES CN1CCN(CC1)C(=O)Cc1c(C)[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc12 Show InChI InChI=1S/C25H26Cl2N6O2/c1-14-16(13-20(34)33-11-9-31(2)10-12-33)15-7-8-19-23(21(15)24(35)28-14)32(3)25(29-19)30-22-17(26)5-4-6-18(22)27/h4-8H,9-13H2,1-3H3,(H,28,35)(H,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase				J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW
					More data for this Ligand-Target Pair