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BDBM50126757 2-(2,6-Dichloro-phenylamino)-7-ethyl-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL27004

SMILES: CCc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C

InChI Key: InChIKey=UMXWSDMSYWQYRR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126757   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50126757
PNG
(2-(2,6-Dichloro-phenylamino)-7-ethyl-1,6-dimethyl-...)
Show SMILES CCc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C
Show InChI InChI=1S/C20H18Cl2N4O/c1-4-14-10(2)11-8-9-15-18(16(11)19(27)23-14)26(3)20(24-15)25-17-12(21)6-5-7-13(17)22/h5-9H,4H2,1-3H3,(H,23,27)(H,24,25)
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Article
PubMed
n/an/a 780n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase


J Med Chem 46: 1337-49 (2003)


Article DOI: 10.1021/jm020446l
BindingDB Entry DOI: 10.7270/Q2DN44FW
More data for this
Ligand-Target Pair