BDBM50127327 2-(4-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL418059

SMILES: Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc(Cl)cc1)c1ccc(cc1)C#N

InChI Key: InChIKey=JRBAIZPPQGWCJN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50127327   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50127327 (2-(4-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc(Cl)cc1)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(19-4-2-17(12-27)3-5-19)32-15-22-11-8-20(13-28)24(30-22)18-6-9-21(26)10-7-18/h2-11,14,16,25H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50127327 (2-(4-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc(Cl)cc1)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(19-4-2-17(12-27)3-5-19)32-15-22-11-8-20(13-28)24(30-22)18-6-9-21(26)10-7-18/h2-11,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I				Bioorg Med Chem Lett 13: 1571-4 (2003) BindingDB Entry DOI: 10.7270/Q27080TK
					More data for this Ligand-Target Pair