BDBM50127835 1-Phenethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-indolizine::CHEMBL299192

SMILES: C(COc1ccc(cc1)-c1cn2ccccc2c1CCc1ccccc1)CN1CCCCC1

InChI Key: InChIKey=UHAPCEXNBHGPIV-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50127835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50127835 (1-Phenethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl...) Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2c1CCc1ccccc1)CN1CCCCC1 Show InChI InChI=1S/C30H34N2O/c1-3-10-25(11-4-1)13-18-28-29(24-32-22-8-5-12-30(28)32)26-14-16-27(17-15-26)33-23-9-21-31-19-6-2-7-20-31/h1,3-5,8,10-12,14-17,22,24H,2,6-7,9,13,18-21,23H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Botswana Curated by ChEMBL					Assay Description Antagonist activity at human histamine H3 receptor				Eur J Med Chem 46: 5237-57 (2011) Article DOI: 10.1016/j.ejmech.2011.08.042 BindingDB Entry DOI: 10.7270/Q2ZG6SNF
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50127835 (1-Phenethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl...) Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2c1CCc1ccccc1)CN1CCCCC1 Show InChI InChI=1S/C30H34N2O/c1-3-10-25(11-4-1)13-18-28-29(24-32-22-8-5-12-30(28)32)26-14-16-27(17-15-26)33-23-9-21-31-19-6-2-7-20-31/h1,3-5,8,10-12,14-17,22,24H,2,6-7,9,13,18-21,23H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development L. L. C. Curated by ChEMBL					Assay Description Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand				Bioorg Med Chem Lett 13: 1767-70 (2003) BindingDB Entry DOI: 10.7270/Q21835V3
					More data for this Ligand-Target Pair