BDBM50127926 5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-thiazolidine-2,4-dione::CHEMBL298187

SMILES: CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O

InChI Key: InChIKey=DMVBZCZXSQAMQH-UHFFFAOYSA-N

Data: 3 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50127926   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity against human PPAR alpha (peroxisome proliferator-activated alpha receptor)				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro agonist activity tested for transactivation in human PPAR delta-GAL4 chimeric COS-1 cells				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
TBA					Assay Description Transactivation activity at Homo sapiens (human) PPARgamma				Citation and Details Article DOI: 10.1007/s00044-010-9428-9 BindingDB Entry DOI: 10.7270/Q22Z18FD
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro agonist activity tested for transactivation in human PPAR alpha-Gal4 chimeric COS-1 cells				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50127926 (5-{3-Chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-prop...) Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(cc1Cl)-c1sc(=O)[nH]c1O Show InChI InChI=1S/C27H26ClNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,30H,2,6-7,14-15H2,1H3,(H,29,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity against human PPAR delta (peroxisome proliferator-activated delta receptor)				Bioorg Med Chem Lett 13: 1801-4 (2003) BindingDB Entry DOI: 10.7270/Q2H994K2
					More data for this Ligand-Target Pair