BDBM50128148 1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-phenyl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol::1,1,1-trifluoro-3-((3-(3-fluoro-2-nitrophenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)propan-2-ol::3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-fluoro-2-nitrophenoxy)phenyl)amino)-1,1,1-trifluoropropan-2-ol::CHEMBL305995
SMILES: OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(F)c2[N+]([O-])=O)c1)C(F)(F)F
InChI Key: InChIKey=XWNQFZQZCQGEMG-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50128148 (1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia Discovery Research (Pfizer Global Research and Development) Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in human serum | J Med Chem 46: 2152-68 (2003) Article DOI: 10.1021/jm020528+ BindingDB Entry DOI: 10.7270/Q2QV3KWK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50128148 (1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia Discovery Research (Pfizer Global Research and Development) Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in buffer | J Med Chem 46: 2152-68 (2003) Article DOI: 10.1021/jm020528+ BindingDB Entry DOI: 10.7270/Q2QV3KWK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50128148 (1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CETP (unknown origin)-mediated [3H]cholesteryl ester transfer from HDL donor particles to LDL acceptor particles | Citation and Details Article DOI: 10.1007/s00044-004-0104-9 BindingDB Entry DOI: 10.7270/Q2SQ9387 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Oryctolagus cuniculus) | BDBM50128148 (1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah Private University of Jordan Curated by ChEMBL | Assay Description Inhibition of CETP in rabbit serum after 1 hr by fluorescent cholesteryl esters transfer assay | Eur J Med Chem 45: 1598-617 (2010) Article DOI: 10.1016/j.ejmech.2009.12.070 BindingDB Entry DOI: 10.7270/Q2VQ32VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50128148 (1,1,1-Trifluoro-3-{[3-(3-fluoro-2-nitro-phenoxy)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal da Bahia Curated by ChEMBL | Assay Description Inhibition of CETP | Bioorg Med Chem 15: 6242-52 (2007) Article DOI: 10.1016/j.bmc.2007.06.021 BindingDB Entry DOI: 10.7270/Q2B857VG | |||||||||||
More data for this Ligand-Target Pair |