BDBM50129124 CHEMBL3629246::US10434085, Compound 8
SMILES: COc1c(Br)c(O)c2c(\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O)c1Br
InChI Key: InChIKey=KKXDLGXFEMMBLI-VFLPEAIRSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens (Human)) | BDBM50129124 (CHEMBL3629246 | US10434085, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Greensboro US Patent | Assay Description The assay was performed at BSP Biosience Inc. (5Z)-7-oxozeaenol was used as a positive control. Analogue 3 was not tested due to the short-term stabi... | US Patent US10434085 (2019) BindingDB Entry DOI: 10.7270/Q2SB483C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens (Human)) | BDBM50129124 (CHEMBL3629246 | US10434085, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Greensboro Curated by ChEMBL | Assay Description Inhibition of TAK1 (unknown origin) | Bioorg Med Chem 23: 6993-9 (2015) BindingDB Entry DOI: 10.7270/Q25D8TNS | |||||||||||
More data for this Ligand-Target Pair |