BDBM50132153 (2,4-Dichloro-5-methoxy-phenyl)-[7-methoxy-8-(2-methoxy-ethoxy)-4a,5,10,10a-tetrahydro-pyrimido[4,5-b]quinolin-4-yl]-amine::CHEMBL100551

SMILES: COCCOc1cc2Nc3ncnc(Nc4cc(OC)c(Cl)cc4Cl)c3Cc2cc1OC

InChI Key: InChIKey=XMAKXDZNYHCNHY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132153   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132153 ((2,4-Dichloro-5-methoxy-phenyl)-[7-methoxy-8-(2-me...) Show SMILES COCCOc1cc2Nc3ncnc(Nc4cc(OC)c(Cl)cc4Cl)c3Cc2cc1OC Show InChI InChI=1S/C22H22Cl2N4O4/c1-29-4-5-32-20-9-16-12(7-19(20)31-3)6-13-21(27-16)25-11-26-22(13)28-17-10-18(30-2)15(24)8-14(17)23/h7-11H,4-6H2,1-3H3,(H2,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 2977-80 (2003) BindingDB Entry DOI: 10.7270/Q2KH0MQX
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132153 ((2,4-Dichloro-5-methoxy-phenyl)-[7-methoxy-8-(2-me...) Show SMILES COCCOc1cc2Nc3ncnc(Nc4cc(OC)c(Cl)cc4Cl)c3Cc2cc1OC Show InChI InChI=1S/C22H22Cl2N4O4/c1-29-4-5-32-20-9-16-12(7-19(20)31-3)6-13-21(27-16)25-11-26-22(13)28-17-10-18(30-2)15(24)8-14(17)23/h7-11H,4-6H2,1-3H3,(H2,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase dependent cellular proliferation				Bioorg Med Chem Lett 13: 2977-80 (2003) BindingDB Entry DOI: 10.7270/Q2KH0MQX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50132153 ((2,4-Dichloro-5-methoxy-phenyl)-[7-methoxy-8-(2-me...) Show SMILES COCCOc1cc2Nc3ncnc(Nc4cc(OC)c(Cl)cc4Cl)c3Cc2cc1OC Show InChI InChI=1S/C22H22Cl2N4O4/c1-29-4-5-32-20-9-16-12(7-19(20)31-3)6-13-21(27-16)25-11-26-22(13)28-17-10-18(30-2)15(24)8-14(17)23/h7-11H,4-6H2,1-3H3,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Fyn dependent cellular proliferation of rat 2 fibroblast cells				Bioorg Med Chem Lett 13: 2977-80 (2003) BindingDB Entry DOI: 10.7270/Q2KH0MQX
					More data for this Ligand-Target Pair