BDBM50132212 4-(6,7-Difluoro-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL100523

SMILES: Fc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1F

InChI Key: InChIKey=PSVGRAFQKMMMBG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50132212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50132212 (4-(6,7-Difluoro-quinazolin-4-yl)-piperazine-1-carb...) Show SMILES Fc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1F Show InChI InChI=1S/C25H21F2N5O2/c26-21-14-20-23(15-22(21)27)28-16-29-24(20)31-10-12-32(13-11-31)25(33)30-17-6-8-19(9-7-17)34-18-4-2-1-3-5-18/h1-9,14-16H,10-13H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells				Bioorg Med Chem Lett 13: 3001-4 (2003) BindingDB Entry DOI: 10.7270/Q2668CKR
					More data for this Ligand-Target Pair