BDBM50132312 17,20-dimethyl-4,14,17,20,23-pentaazahexacyclo[21.6.1.17,14.02,6.08,13.024,29]hentriaconta-1(30),2(6),7(31),8(13),9,11,24(29),25,27-nonaene-3,5-dione::CHEMBL319265
SMILES: CN1CCN(C)CCn2cc(C3=C(C(=O)NC3=O)c3cn(CC1)c1ccccc31)c1ccccc21
InChI Key: InChIKey=CNPLEVGVGWVFGT-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50132312 (17,20-dimethyl-4,14,17,20,23-pentaazahexacyclo[21....) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of Protein kinase C beta 1 | Bioorg Med Chem Lett 13: 3049-53 (2003) BindingDB Entry DOI: 10.7270/Q2DR2TVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50132312 (17,20-dimethyl-4,14,17,20,23-pentaazahexacyclo[21....) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of Platelet-derived growth factor receptor | Bioorg Med Chem Lett 13: 3049-53 (2003) BindingDB Entry DOI: 10.7270/Q2DR2TVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM50132312 (17,20-dimethyl-4,14,17,20,23-pentaazahexacyclo[21....) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of Glycogen synthase kinase-3 beta | Bioorg Med Chem Lett 13: 3049-53 (2003) BindingDB Entry DOI: 10.7270/Q2DR2TVT | |||||||||||
More data for this Ligand-Target Pair |