BDBM50132430 3-[1-(4-Methanesulfonyl-phenyl)-meth-(Z)-ylidene]-5-(thiophene-2-carbonyl)-1,3-dihydro-indol-2-one::CHEMBL104640

SMILES: CS(=O)(=O)c1ccc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2cccs2)cc1

InChI Key: InChIKey=FOLGHFINWYEFPE-BOPFTXTBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50132430   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50132430 (3-[1-(4-Methanesulfonyl-phenyl)-meth-(Z)-ylidene]-...) Show SMILES CS(=O)(=O)c1ccc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2cccs2)cc1 Show InChI InChI=1S/C21H15NO4S2/c1-28(25,26)15-7-4-13(5-8-15)11-17-16-12-14(6-9-18(16)22-21(17)24)20(23)19-3-2-10-27-19/h2-12H,1H3,(H,22,24)/b17-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.				Bioorg Med Chem Lett 13: 3105-10 (2003) BindingDB Entry DOI: 10.7270/Q2833RDR
					More data for this Ligand-Target Pair