BDBM50132431 3-[1-Phenyl-meth-(Z)-ylidene]-5-(thiophene-2-carbonyl)-1,3-dihydro-indol-2-one::CHEMBL321855

SMILES: O=C(c1cccs1)c1ccc2NC(=O)\C(=C/c3ccccc3)c2c1

InChI Key: InChIKey=JLQAHOQUHARADH-WJDWOHSUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50132431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50132431 (3-[1-Phenyl-meth-(Z)-ylidene]-5-(thiophene-2-carbo...) Show SMILES O=C(c1cccs1)c1ccc2NC(=O)\C(=C/c3ccccc3)c2c1 Show InChI InChI=1S/C20H13NO2S/c22-19(18-7-4-10-24-18)14-8-9-17-15(12-14)16(20(23)21-17)11-13-5-2-1-3-6-13/h1-12H,(H,21,23)/b16-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.				Bioorg Med Chem Lett 13: 3105-10 (2003) BindingDB Entry DOI: 10.7270/Q2833RDR
					More data for this Ligand-Target Pair