BDBM50132988 4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline::CHEMBL341280

SMILES: Brc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12

InChI Key: InChIKey=DIDDNVPEZKJYOM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132988   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132988 (4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...) Show SMILES Brc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12 Show InChI InChI=1S/C17H11BrN4/c18-16-7-3-6-15(21-16)17-13(10-20-22-17)11-8-9-19-14-5-2-1-4-12(11)14/h1-10H,(H,20,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132988 (4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...) Show SMILES Brc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12 Show InChI InChI=1S/C17H11BrN4/c18-16-7-3-6-15(21-16)17-13(10-20-22-17)11-8-9-19-14-5-2-1-4-12(11)14/h1-10H,(H,20,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132988 (4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...) Show SMILES Brc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12 Show InChI InChI=1S/C17H11BrN4/c18-16-7-3-6-15(21-16)17-13(10-20-22-17)11-8-9-19-14-5-2-1-4-12(11)14/h1-10H,(H,20,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Mitogen-activated protein kinase p38				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132988 (4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...) Show SMILES Brc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12 Show InChI InChI=1S/C17H11BrN4/c18-16-7-3-6-15(21-16)17-13(10-20-22-17)11-8-9-19-14-5-2-1-4-12(11)14/h1-10H,(H,20,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
					More data for this Ligand-Target Pair