BDBM50133005 (5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone::(5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone::CHEMBL128613

SMILES: CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1

InChI Key: InChIKey=UNZKXQGDHWYPDV-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50133005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50133005 ((5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1 Show InChI InChI=1S/C14H16BrN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells				J Med Chem 48: 8289-98 (2005) Article DOI: 10.1021/jm0502081 BindingDB Entry DOI: 10.7270/Q2C24W00
					More data for this Ligand-Target Pair
Histamine receptor (H3 and H4) (Homo sapiens (Human))	BDBM50133005 ((5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1 Show InChI InChI=1S/C14H16BrN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at Homo sapiens (human) histamine H4 receptor				Citation and Details Article DOI: 10.1007/s00044-004-0106-7 BindingDB Entry DOI: 10.7270/Q2J9697T
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50133005 ((5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1 Show InChI InChI=1S/C14H16BrN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]- histamine from the recombinant human histamine H4 receptor				J Med Chem 46: 3957-60 (2003) Article DOI: 10.1021/jm0341047 BindingDB Entry DOI: 10.7270/Q2QJ7J1C
					More data for this Ligand-Target Pair
Histamine receptor (H3 and H4) (Homo sapiens (Human))	BDBM50133005 ((5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1 Show InChI InChI=1S/C14H16BrN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	8.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at Homo sapiens (human) histamine H4 receptor				Citation and Details Article DOI: 10.1007/s00044-004-0106-7 BindingDB Entry DOI: 10.7270/Q2J9697T
					More data for this Ligand-Target Pair