BDBM50133461 4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-3,6-dihydro-2H-pyridine-1-carbothioic acid adamantan-1-ylamide::CHEMBL323705
SMILES: CN1CCC[C@@H]1Cc1c[nH]c2ccc(cc12)C1=CCN(CC1)C(=S)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
InChI Key: InChIKey=OOMJLEPTKROOJB-RNOFISPHSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50133461 (4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor | Bioorg Med Chem Lett 13: 3419-21 (2003) BindingDB Entry DOI: 10.7270/Q2PZ587T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50133461 (4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 1B receptor | Bioorg Med Chem Lett 13: 3419-21 (2003) BindingDB Entry DOI: 10.7270/Q2PZ587T | |||||||||||
More data for this Ligand-Target Pair |