BDBM50133928 1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-butan-1-one::CHEMBL341774

SMILES: Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1

InChI Key: InChIKey=CDMKFCYALGWSEN-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50133928   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50133928 (1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...) Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1 Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	83.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Ability to compete with [3H]YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cells				J Med Chem 46: 4377-92 (2003) Article DOI: 10.1021/jm030085p BindingDB Entry DOI: 10.7270/Q21V5FPS
					More data for this Ligand-Target Pair
Dopamine receptor (RAT)	BDBM50133928 (1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...) Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1 Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	243	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membrane				J Med Chem 48: 3171-81 (2005) Article DOI: 10.1021/jm049031l BindingDB Entry DOI: 10.7270/Q2NZ874W
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50133928 (1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...) Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1 Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	304	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Binding affinity D3 [3H]-PD 128907 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats				Bioorg Med Chem Lett 15: 1701-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.037 BindingDB Entry DOI: 10.7270/Q2862FXD
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50133928 (1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...) Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1 Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	304	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatum				J Med Chem 48: 3171-81 (2005) Article DOI: 10.1021/jm049031l BindingDB Entry DOI: 10.7270/Q2NZ874W
					More data for this Ligand-Target Pair
Dopamine D1B (RAT)	BDBM50133928 (1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...) Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1 Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	904	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain				J Med Chem 48: 3171-81 (2005) Article DOI: 10.1021/jm049031l BindingDB Entry DOI: 10.7270/Q2NZ874W
					More data for this Ligand-Target Pair