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BDBM50134136 (R)-10-(4-Methoxy-phenyl)-2-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione::CHEMBL142143

SMILES: COc1ccc(cc1)C1c2[nH]c3ccccc3c2Cc2c(O)n(C)c(=O)n12

InChI Key: InChIKey=XOPAODYMIVJJNI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134136   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 5A


(Bos taurus)
BDBM50134136
PNG
((R)-10-(4-Methoxy-phenyl)-2-methyl-3a,4,9,10-tetra...)
Show SMILES COc1ccc(cc1)C1c2[nH]c3ccccc3c2Cc2c(O)n(C)c(=O)n12
Show InChI InChI=1S/C21H19N3O3/c1-23-20(25)17-11-15-14-5-3-4-6-16(14)22-18(15)19(24(17)21(23)26)12-7-9-13(27-2)10-8-12/h3-10,19,22,25H,11H2,1-2H3
PDB
MMDB

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n/an/a 10n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine phosphodiesterase 5


J Med Chem 46: 4533-42 (2003)


Article DOI: 10.1021/jm0300577
BindingDB Entry DOI: 10.7270/Q2N015X2
More data for this
Ligand-Target Pair