BindingDB PrimarySearch

BDBM50134378 (2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylamino)pentanoic acid::(2S)-5-{[amino(imino)methyl]amino}-2-(methylamino)pentanoic acid::(S)-5-Guanidino-2-methylamino-pentanoic acid::(S)-5-guanidino-2-(methylamino)pentanoic acid::CHEMBL332148::N-Monomethyl-L-arginine::N~5~-(DIAMINOMETHYLENE)-N~2~-METHYLORNITHINE

SMILES: [#6]-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O

InChI Key: InChIKey=NTWVQPHTOUKMDI-YFKPBYRVSA-N

Data: 5 IC50

PDB links: 6 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50134378
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50134378 ((2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibitory concentration against neuronal nitric acid synthase				Bioorg Med Chem Lett 15: 1361-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.013 BindingDB Entry DOI: 10.7270/Q2G160B2
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50134378 ((2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibitory concentration against inducible nitric acid synthase				Bioorg Med Chem Lett 15: 1361-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.013 BindingDB Entry DOI: 10.7270/Q2G160B2
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50134378 ((2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylam...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...				J Med Chem 55: 3488-501 (2012) Article DOI: 10.1021/jm300138g BindingDB Entry DOI: 10.7270/Q2KW5H2V
NeurAxon Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50134378 ((2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...				J Med Chem 55: 3488-501 (2012) Article DOI: 10.1021/jm300138g BindingDB Entry DOI: 10.7270/Q2KW5H2V
NeurAxon Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50134378 ((2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...				J Med Chem 55: 3488-501 (2012) Article DOI: 10.1021/jm300138g BindingDB Entry DOI: 10.7270/Q2KW5H2V
NeurAxon Inc. Curated by ChEMBL					More data for this Ligand-Target Pair