null

SMILES: COc1cccc(Nc2c(cnc3c(C(C)C)c(nn23)S(C)(=O)=O)C(N)=O)c1

InChI Key: InChIKey=GYKIIBHKVXZXBY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134430   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50134430 (CHEMBL3747248) Show SMILES COc1cccc(Nc2c(cnc3c(C(C)C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C18H21N5O4S/c1-10(2)14-17-20-9-13(15(19)24)16(23(17)22-18(14)28(4,25)26)21-11-6-5-7-12(8-11)27-3/h5-10,21H,1-4H3,(H2,19,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP				Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50134430 (CHEMBL3747248) Show SMILES COc1cccc(Nc2c(cnc3c(C(C)C)c(nn23)S(C)(=O)=O)C(N)=O)c1 Show InChI InChI=1S/C18H21N5O4S/c1-10(2)14-17-20-9-13(15(19)24)16(23(17)22-18(14)28(4,25)26)21-11-6-5-7-12(8-11)27-3/h5-10,21H,1-4H3,(H2,19,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay				Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair