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SMILES: Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2c(Cn3cncn3)ccc3ccccc23)cc1

InChI Key: InChIKey=SXSUTNPGZOKCAQ-CZNDPXEESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134504   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50134504
PNG
((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2c(Cn3cncn3)ccc3ccccc23)cc1
Show InChI InChI=1S/C36H36ClN7O2/c37-30-13-9-25(10-14-30)19-33(41-35(45)32-20-27-6-1-2-7-28(27)21-39-32)36(46)43-17-15-42(16-18-43)34-29(22-44-24-38-23-40-44)12-11-26-5-3-4-8-31(26)34/h1-14,23-24,32-33,39H,15-22H2,(H,41,45)/t32-,33-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 170n/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Agonistic activity measured as inhibition of cAMP accumulation in HEK cells expressing human Melanocortin 4 receptor (hMC4R)

Bioorg Med Chem Lett 13: 3793-6 (2003)


BindingDB Entry DOI: 10.7270/Q2P26ZNW
More data for this
Ligand-Target Pair