BDBM50135190 CHEMBL3745973

SMILES: O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12

InChI Key: InChIKey=IHYUWEFWDRDISB-UNMCSNQZSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50135190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135190 (CHEMBL3745973) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C24H25N5O2/c30-22-7-2-1-5-20(22)27-24(31)19-16-28(21-6-3-12-25-23(19)21)15-17-8-10-18(11-9-17)29-14-4-13-26-29/h3-4,6,8-14,16,20,22,30H,1-2,5,7,15H2,(H,27,31)/t20-,22-/m0/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	106	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level...				Bioorg Med Chem Lett 28: 2068-2073 (2018) Article DOI: 10.1016/j.bmcl.2018.04.054 BindingDB Entry DOI: 10.7270/Q2TB19HB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135190 (CHEMBL3745973) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r| Show InChI InChI=1S/C24H25N5O2/c30-22-7-2-1-5-20(22)27-24(31)19-16-28(21-6-3-12-25-23(19)21)15-17-8-10-18(11-9-17)29-14-4-13-26-29/h3-4,6,8-14,16,20,22,30H,1-2,5,7,15H2,(H,27,31)/t20-,22-/m0/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	101	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair