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BDBM50135191 CHEMBL3746904

SMILES: O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc3ncccc3c2)c2cccnc12

InChI Key: InChIKey=NZABUGASWCRVSP-UNMCSNQZSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135191   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50135191
PNG
(CHEMBL3746904)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc3ncccc3c2)c2cccnc12 |r|
Show InChI InChI=1S/C24H24N4O2/c29-22-8-2-1-6-20(22)27-24(30)18-15-28(21-7-4-12-26-23(18)21)14-16-9-10-19-17(13-16)5-3-11-25-19/h3-5,7,9-13,15,20,22,29H,1-2,6,8,14H2,(H,27,30)/t20-,22-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 185n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay

Bioorg Med Chem Lett 26: 650-5 (2016)


BindingDB Entry DOI: 10.7270/Q29C708F
More data for this
Ligand-Target Pair