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SMILES: O=C(NC[C@@H]1CCCO1)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12

InChI Key: InChIKey=SFRBLETWXOYWNV-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135204   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50135204
PNG
(CHEMBL3747254)
Show SMILES O=C(NC[C@@H]1CCCO1)c1cn(Cc2ccc(cc2)-n2cccn2)c2cccnc12 |r|
Show InChI InChI=1S/C23H23N5O2/c29-23(25-14-19-4-2-13-30-19)20-16-27(21-5-1-10-24-22(20)21)15-17-6-8-18(9-7-17)28-12-3-11-26-28/h1,3,5-12,16,19H,2,4,13-15H2,(H,25,29)/t19-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 175n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay

Bioorg Med Chem Lett 26: 650-5 (2016)


BindingDB Entry DOI: 10.7270/Q29C708F
More data for this
Ligand-Target Pair