BDBM50135215 CHEMBL3745724

SMILES: Cc1ccc2n(Cc3ccc(cc3)-c3ccn(C)n3)cc(C(=O)N[C@H]3CCOC[C@@H]3O)c2n1

InChI Key: InChIKey=LFFQWOVZSJTNST-GMAHTHKFSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50135215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135215 (CHEMBL3745724) Show SMILES Cc1ccc2n(Cc3ccc(cc3)-c3ccn(C)n3)cc(C(=O)N[C@H]3CCOC[C@@H]3O)c2n1 |r| Show InChI InChI=1S/C25H27N5O3/c1-16-3-8-22-24(26-16)19(25(32)27-21-10-12-33-15-23(21)31)14-30(22)13-17-4-6-18(7-5-17)20-9-11-29(2)28-20/h3-9,11,14,21,23,31H,10,12-13,15H2,1-2H3,(H,27,32)/t21-,23-/m0/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	255	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level...				Bioorg Med Chem Lett 28: 2068-2073 (2018) Article DOI: 10.1016/j.bmcl.2018.04.054 BindingDB Entry DOI: 10.7270/Q2TB19HB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50135215 (CHEMBL3745724) Show SMILES Cc1ccc2n(Cc3ccc(cc3)-c3ccn(C)n3)cc(C(=O)N[C@H]3CCOC[C@@H]3O)c2n1 |r| Show InChI InChI=1S/C25H27N5O3/c1-16-3-8-22-24(26-16)19(25(32)27-21-10-12-33-15-23(21)31)14-30(22)13-17-4-6-18(7-5-17)20-9-11-29(2)28-20/h3-9,11,14,21,23,31H,10,12-13,15H2,1-2H3,(H,27,32)/t21-,23-/m0/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	293	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 650-5 (2016) BindingDB Entry DOI: 10.7270/Q29C708F
					More data for this Ligand-Target Pair