null

SMILES: Cn1c(COC(c2cncs2)c2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=FPVFNTHWCRWGPI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50135385   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50135385 (6-[(4-Cyano-phenyl)-thiazol-5-yl-methoxymethyl]-1-...) Show SMILES Cn1c(COC(c2cncs2)c2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H17F3N4O3S/c1-33-22(14-35-24(23-13-32-15-37-23)18-4-2-16(11-30)3-5-18)21(10-19(12-31)25(33)34)17-6-8-20(9-7-17)36-26(27,28)29/h2-10,13,15,24H,14H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50135385 (6-[(4-Cyano-phenyl)-thiazol-5-yl-methoxymethyl]-1-...) Show SMILES Cn1c(COC(c2cncs2)c2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H17F3N4O3S/c1-33-22(14-35-24(23-13-32-15-37-23)18-4-2-16(11-30)3-5-18)21(10-19(12-31)25(33)34)17-6-8-20(9-7-17)36-26(27,28)29/h2-10,13,15,24H,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair