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BDBM50135423 Biphenyl-2-carboxylic acid {4-[2-(2-tetrazol-1-yl-ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazepine-5-carbonyl]-phenyl}-amide::CHEMBL131727

SMILES: O=C(Nc1ccc(cc1)C(=O)N1CCC(CCn2cnnn2)Sc2ccccc12)c1ccccc1-c1ccccc1

InChI Key: InChIKey=FSRUNLWNRVHFTN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135423   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vasopressin V2 receptor


(Homo sapiens (Human))		BDBM50135423
PNG
(Biphenyl-2-carboxylic acid {4-[2-(2-tetrazol-1-yl-...)
Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCC(CCn2cnnn2)Sc2ccccc12)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C32H28N6O2S/c39-31(28-11-5-4-10-27(28)23-8-2-1-3-9-23)34-25-16-14-24(15-17-25)32(40)38-21-19-26(18-20-37-22-33-35-36-37)41-30-13-7-6-12-29(30)38/h1-17,22,26H,18-21H2,(H,34,39)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 20n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Ability to displace [3H]-arginine vasopressin in cloned human V2 receptor at 0.2 uM

Bioorg Med Chem Lett 13: 4031-4 (2003)


BindingDB Entry DOI: 10.7270/Q23T9GM3
More data for this
Ligand-Target Pair