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SMILES: Cn1cnnc1C(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1

InChI Key: InChIKey=AIZAXCJJFKTNIA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50136377   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136377
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl...)
Show SMILES Cn1cnnc1C(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C26H20Cl2N4O/c1-31-15-29-30-26(31)25(16-6-9-19(27)10-7-16)18-8-11-23-22(13-18)21(14-24(33)32(23)2)17-4-3-5-20(28)12-17/h3-15,25H,1-2H3
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MMDB

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n/an/a 1n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair