BindingDB PrimarySearch

BDBM50137278 2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::2-(2,5-dichlorophenylsulfonyl)-N,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL424130

SMILES: ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl

InChI Key: InChIKey=QMIAXILIKVOPKK-UHFFFAOYSA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50137278
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-9 (MMP-9)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-14 (MMP-14)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-12 (MMP-12)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 15 (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.79E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-15 (MMP-15)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
Pomona College Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 26 (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-26 (MMP-26)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 16 (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-16 (MMP-16)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	853	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-2 (MMP-2)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50137278 (2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-7 (MMP-7)				Bioorg Med Chem Lett 14: 47-50 (2003) BindingDB Entry DOI: 10.7270/Q22J6B79
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair