BDBM50137585 5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL55594

SMILES: CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1

InChI Key: InChIKey=DDQFACKDLYLRGU-RGEXLXHISA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50137585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Lck tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Yes tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Vascular endothelial growth factor receptor 2				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Src protein tryrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Fyn tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Src protein tryrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50137585 (5-Ethanesulfonyl-3-[1-(3-morpholin-4-ylmethyl-4,5,...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CN3CCOCC3)c2c1 Show InChI InChI=1S/C24H29N3O4S/c1-2-32(29,30)16-7-8-22-18(13-16)19(24(28)26-22)14-23-20(15-27-9-11-31-12-10-27)17-5-3-4-6-21(17)25-23/h7-8,13-14,25H,2-6,9-12,15H2,1H3,(H,26,28)/b19-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Fibroblast growth factor receptor 1				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair