BDBM50137647 CHEMBL3752085

SMILES: CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1

InChI Key: InChIKey=NIACEGZKGSHPHM-UHFFFAOYSA-N

Data: 4 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50137647   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50137647 (CHEMBL3752085) Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	955	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander-Universit£t Erlangen-N£rnberg Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation counting				Bioorg Med Chem Lett 26: 292-300 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B0K
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50137647 (CHEMBL3752085) Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander-Universit£t Erlangen-N£rnberg Curated by ChEMBL					Assay Description Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation counting				Bioorg Med Chem Lett 26: 292-300 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B0K
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50137647 (CHEMBL3752085) Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander-Universit£t Erlangen-N£rnberg Curated by ChEMBL					Assay Description Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation counting				Bioorg Med Chem Lett 26: 292-300 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B0K
					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM50137647 (CHEMBL3752085) Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander-Universit£t Erlangen-N£rnberg Curated by ChEMBL					Assay Description Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation counting				Bioorg Med Chem Lett 26: 292-300 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B0K
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50137647 (CHEMBL3752085) Show SMILES CN1CCN(CC1)c1cc(nc(NCc2ccccc2)n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-26-12-14-27(15-13-26)21-16-20(19-10-6-3-7-11-19)24-22(25-21)23-17-18-8-4-2-5-9-18/h2-11,16H,12-15,17H2,1H3,(H,23,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	912	n/a	n/a	n/a	n/a
Friedrich-Alexander-Universit£t Erlangen-N£rnberg Curated by ChEMBL					Assay Description Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...				Bioorg Med Chem Lett 26: 292-300 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B0K
					More data for this Ligand-Target Pair