BDBM50138404 CHEMBL138054::[(2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-4-fluoro-2,5-dihydrofuran-2-yl]methyl tetrahydrogen triphosphate

SMILES: Nc1nc(=O)n(cc1F)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=C1F

InChI Key: InChIKey=PROAGFUPQSQUOK-VHWMUFPASA-N

Data: 1 Kd

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50138404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50138404 (CHEMBL138054 | [(2R,5S)-5-(4-amino-5-fluoro-2-oxop...) Show SMILES Nc1nc(=O)n(cc1F)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=C1F |c:27| Show InChI InChI=1S/C9H12F2N3O12P3/c10-5-1-4(24-8(5)14-2-6(11)7(12)13-9(14)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,8H,3H2,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t4-,8+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a	n/a
The University of Georgia Curated by ChEMBL					Assay Description Equilibrium binding constant at the active site of HIV-1 reverse transcriptase				Bioorg Med Chem Lett 14: 437-40 (2003) BindingDB Entry DOI: 10.7270/Q2RX9BGK
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