BDBM50139197 4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide::CHEMBL156225

SMILES: OCC(O)Cc1ccc2Oc3cc(Cn4cncc4CN4CCN(Cc1c2)C(=O)C4)ccc3C#N

InChI Key: InChIKey=RJMUYANIARJTKU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50139197   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139197 (4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-te...) Show SMILES OCC(O)Cc1ccc2Oc3cc(Cn4cncc4CN4CCN(Cc1c2)C(=O)C4)ccc3C#N Show InChI InChI=1S/C26H27N5O4/c27-10-20-2-1-18-7-25(20)35-24-4-3-19(8-23(33)16-32)21(9-24)13-30-6-5-29(15-26(30)34)14-22-11-28-17-31(22)12-18/h1-4,7,9,11,17,23,32-33H,5-6,8,12-16H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-terminus of human K...				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139197 (4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-te...) Show SMILES OCC(O)Cc1ccc2Oc3cc(Cn4cncc4CN4CCN(Cc1c2)C(=O)C4)ccc3C#N Show InChI InChI=1S/C26H27N5O4/c27-10-20-2-1-18-7-25(20)35-24-4-3-19(8-23(33)16-32)21(9-24)13-30-6-5-29(15-26(30)34)14-22-11-28-17-31(22)12-18/h1-4,7,9,11,17,23,32-33H,5-6,8,12-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139197 (4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-te...) Show SMILES OCC(O)Cc1ccc2Oc3cc(Cn4cncc4CN4CCN(Cc1c2)C(=O)C4)ccc3C#N Show InChI InChI=1S/C26H27N5O4/c27-10-20-2-1-18-7-25(20)35-24-4-3-19(8-23(33)16-32)21(9-24)13-30-6-5-29(15-26(30)34)14-22-11-28-17-31(22)12-18/h1-4,7,9,11,17,23,32-33H,5-6,8,12-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair