BDBM50139473 CHEMBL3763689

SMILES: CC(C)(C)OC(=O)N(Cc1cncn1Cc1ccc(cc1)C#N)c1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1

InChI Key: InChIKey=XRIYELGXTNWKPU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139473   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139473 (CHEMBL3763689) Show SMILES CC(C)(C)OC(=O)N(Cc1cncn1Cc1ccc(cc1)C#N)c1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C29H24ClN5O4S/c1-29(2,3)39-28(38)35(16-22-14-33-17-34(22)15-19-6-4-18(12-31)5-7-19)26-23(13-32)24(25(40-26)27(36)37)20-8-10-21(30)11-9-20/h4-11,14,17H,15-16H2,1-3H3,(H,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UPR2301 Curated by ChEMBL					Assay Description Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay				Eur J Med Chem 109: 173-86 (2016) BindingDB Entry DOI: 10.7270/Q25B04C6
					More data for this Ligand-Target Pair