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SMILES: FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)Nc3cccnc3)cc2)ccc1Cl

InChI Key: InChIKey=NFZINQPVSSYWKG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139626   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50139626
PNG
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)Nc3cccnc3)cc2)ccc1Cl
Show InChI InChI=1S/C26H18ClF3N4O3/c27-23-11-8-18(14-22(23)26(28,29)30)34-25(36)33-17-6-9-20(10-7-17)37-21-5-1-3-16(13-21)24(35)32-19-4-2-12-31-15-19/h1-15H,(H,32,35)(H2,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 44n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against human Raf-1 kinase

Bioorg Med Chem Lett 14: 783-6 (2004)


BindingDB Entry DOI: 10.7270/Q2TM79JT
More data for this
Ligand-Target Pair